3n4b Summary


Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor

The structure was published by Pacchiano, F., Aggarwal, M., Avvaru, B.S., et al., Scozzafava, A., McKenna, R., and Supuran, C.T., in 2010 in a paper entitled "Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 96% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch morphogenesis of an epitheliumsearch kidney developmentsearch response to steroid hormonesearch response to zinc ionsearch response to organic substancesearch regulation of intracellular pHsearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of bone resorptionsearch regulation of anion transportsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch positive regulation of dipeptide transmembrane transportsearch secretionsearch response to pHsearch response to estrogensearch positive regulation of cellular pH reductionsearch positive regulation of osteoclast differentiationsearch cellular response to fluid shear stresssearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch arylesterase activitysearch metal ion bindingsearch protein bindingsearch basolateral plasma membranesearch cytoplasmsearch plasma membranesearch cytosolsearch apical part of cellsearch microvillussearch extracellular exosomesearch axonsearch membranesearch myelin sheathsearch extracellular spacesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch