3n3i Summary


Crystal Structure of G48V/C95F tethered HIV-1 Protease/Saquinavir complex

The structure was published by Prashar, V., Bihani, S.C., Das, A., Rao, D.R., and Hosur, M.V., in 2010 in a paper entitled "Insights into the mechanism of drug resistance: X-ray structure analysis of G48V/C95F tethered HIV-1 protease dimer/saquinavir complex" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.501 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protease. This molecule has the UniProt identifier P04585 (POL_HV1H2)search. The sample contained 203 residues which is < 90% of the natural sequence. Out of 203 residues 198 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protease P04585 (484-488) (POL_HV1H2)search ,
P04585 (489-587) (POL_HV1H2)search
HIV-1 M:B_HXB2Rsearch ,
HIV-1 M:B_HXB2Rsearch
< 90% ,
< 90%
203 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04585 (484 - 488) Protease HIV-1 M:B_HXB2R

Chain Structural classification (CATH) Sequence family (Pfam)
A Acid Proteasessearch Retroviral aspartyl proteasesearch
Chain InterPro annotation
A Aspartic peptidase, active sitesearch Peptidase A2A, retrovirus, catalyticsearch Peptidase A2A, retrovirus RVP subgroupsearch Aspartic peptidase domainsearch