3n0n Summary


Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor

The structure was published by Pacchiano, F., Aggarwal, M., Avvaru, B.S., et al., Scozzafava, A., McKenna, R., and Supuran, C.T., in 2010 in a paper entitled "Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch metal ion bindingsearch zinc ion bindingsearch regulation of chloride transportsearch positive regulation of bone resorptionsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch odontogenesis of dentin-containing toothsearch one-carbon metabolic processsearch positive regulation of cellular pH reductionsearch morphogenesis of an epitheliumsearch angiotensin-activated signaling pathwaysearch response to estrogensearch positive regulation of osteoclast differentiationsearch kidney developmentsearch positive regulation of synaptic transmission, GABAergicsearch secretionsearch regulation of anion transportsearch regulation of intracellular pHsearch response to organic substancesearch response to zinc ionsearch response to steroid hormonesearch small molecule metabolic processsearch cytoplasmsearch microvillussearch plasma membranesearch cytosolsearch extracellular vesicular exosomesearch extracellular spacesearch apical part of cellsearch axonsearch myelin sheathsearch basolateral plasma membranesearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch