3mzc Summary


Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor

The structure was published by Pacchiano, F., Aggarwal, M., Avvaru, B.S., et al., Scozzafava, A., McKenna, R., and Supuran, C.T., in 2010 in a paper entitled "Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.498 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch protein bindingsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch secretionsearch small molecule metabolic processsearch response to pHsearch one-carbon metabolic processsearch positive regulation of dipeptide transmembrane transportsearch response to organic substancesearch cellular response to fluid shear stresssearch response to zinc ionsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch response to steroid hormonesearch response to estrogensearch morphogenesis of an epitheliumsearch odontogenesis of dentin-containing toothsearch kidney developmentsearch regulation of intracellular pHsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of osteoclast differentiationsearch regulation of chloride transportsearch regulation of anion transportsearch myelin sheathsearch extracellular spacesearch cytoplasmsearch plasma membranesearch membranesearch microvillussearch cytosolsearch apical part of cellsearch axonsearch basolateral plasma membranesearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch