Aurora A Kinase complexed with SCH 1473759
The structure was published by Yu, T., Tagat, J.R., Kerekes, A.D., et al., Ramanathan, L., Prosise, W., and Hu, M., in 2010 in a paper entitled "Discovery of a Potent and Injectable Inhibitor of Aurora Kinases A and B based on the Imidazo-[1, 2-a]-Pyrazine Core" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Serine/threonine-protein kinase 6. This molecule has the UniProt identifier O14965 (AURKA_HUMAN). The sample contained 272 residues which is < 90% of the natural sequence. Out of 272 residues 252 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: