3mw1 Summary


p38 kinase Crystal structure in complex with small molecule inhibitor

The structure was published by Lumeras, W., Vidal, L., Vidal, B., et al., Dominguez, M., Segarra, V., and Caturla, F., in 2011 in a paper entitled "1,7-Naphthyridine 1-Oxides as Novel Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 359 residues which is 100% of the natural sequence. Out of 359 residues 337 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 359 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein kinase activitysearch MAP kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch nucleotide bindingsearch MAP kinase kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch NFAT protein bindingsearch transferase activitysearch protein phosphorylationsearch toll-like receptor signaling pathwaysearch cellular response to ionizing radiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch apoptotic processsearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to DNA damage stimulussearch cartilage condensationsearch skeletal muscle tissue developmentsearch intracellular signal transductionsearch transcription, DNA-templatedsearch positive regulation of myotube differentiationsearch regulation of transcription, DNA-templatedsearch toll-like receptor 5 signaling pathwaysearch osteoclast differentiationsearch RNA metabolic processsearch response to lipopolysaccharidesearch muscle cell differentiationsearch DNA damage checkpointsearch response to muramyl dipeptidesearch stress-induced premature senescencesearch myoblast differentiation involved in skeletal muscle regenerationsearch MyD88-dependent toll-like receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 9 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of protein import into nucleussearch cellular response to lipopolysaccharidesearch positive regulation of erythrocyte differentiationsearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch cell surface receptor signaling pathwaysearch angiogenesissearch striated muscle cell differentiationsearch blood coagulationsearch chondrocyte differentiationsearch positive regulation of myoblast differentiationsearch stress-activated MAPK cascadesearch negative regulation of canonical Wnt signaling pathwaysearch fatty acid oxidationsearch platelet activationsearch positive regulation of myoblast fusionsearch signal transductionsearch toll-like receptor 10 signaling pathwaysearch glucose metabolic processsearch cell morphogenesissearch cellular component movementsearch p38MAPK cascadesearch positive regulation of muscle cell differentiationsearch signal transduction in response to DNA damagesearch gene expressionsearch Ras protein signal transductionsearch toll-like receptor 2 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch innate immune responsesearch cellular response to vascular endothelial growth factor stimulussearch activation of MAPK activitysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch phosphorylationsearch toll-like receptor 3 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of transcription from RNA polymerase II promotersearch response to stresssearch mRNA metabolic processsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of reactive oxygen species metabolic processsearch chemotaxissearch cytoplasmsearch nucleoplasmsearch cytosolsearch spindle polesearch extracellular vesicular exosomesearch nucleussearch mitochondrionsearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch