3mtf Summary


Crystal structure of the ACVR1 kinase in complex with a 2-aminopyridine inhibitor

The structure was published by Sanvitale, C.E., Kerr, G., Chaikuad, A., et al., Yu, P.B., Hill, C.S., and Bullock, A.N., in 2013 in a paper entitled "A new class of small molecule inhibitor of BMP signaling." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Activin receptor type-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Activin receptor type-1 Q04771 (201-499) (ACVR1_HUMAN)search Homo sapienssearch < 90% 301 99%
B Activin receptor type-1 Q04771 (201-499) (ACVR1_HUMAN)search Homo sapienssearch < 90% 301 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q04771 (201 - 499) Activin receptor type-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Transforming growth factor beta type I GS-motifsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q04771) protein kinase activitysearch protein serine/threonine kinase activitysearch receptor signaling protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch regulation of signal transductionsearch membranesearch

Chain InterPro annotation
A, B Ser/Thr protein kinase, TGFB receptorsearch Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch