3mnk Summary


Human Carbonic Anhydrase II Mutant K170H

The structure was published by Domsic, J.F., Williams, W., Fisher, S.Z., et al., Agbandje-McKenna, M., Silverman, D.N., and McKenna, R., in 2010 in a paper entitled "Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch bicarbonate transportsearch positive regulation of bone resorptionsearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch response to pHsearch response to organic substancesearch response to zinc ionsearch secretionsearch one-carbon metabolic processsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch response to estrogensearch kidney developmentsearch positive regulation of synaptic transmission, GABAergicsearch apical part of cellsearch axonsearch cytosolsearch microvillussearch basolateral plasma membranesearch membranesearch cytoplasmsearch extracellular vesicular exosomesearch plasma membranesearch myelin sheathsearch extracellular spacesearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch