3mnj Summary


Human Carbonic Anhydrase II Mutant K170E

The structure was published by Domsic, J.F., Williams, W., Fisher, S.Z., et al., Agbandje-McKenna, M., Silverman, D.N., and McKenna, R., in 2010 in a paper entitled "Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytosolsearch plasma membranesearch myelin sheathsearch apical part of cellsearch extracellular spacesearch membranesearch microvillussearch extracellular vesicular exosomesearch cytoplasmsearch axonsearch basolateral plasma membranesearch positive regulation of bone resorptionsearch angiotensin-activated signaling pathwaysearch response to organic substancesearch bicarbonate transportsearch small molecule metabolic processsearch response to steroid hormonesearch one-carbon metabolic processsearch positive regulation of cellular pH reductionsearch response to zinc ionsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of osteoclast differentiationsearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch kidney developmentsearch regulation of chloride transportsearch response to pHsearch odontogenesis of dentin-containing toothsearch secretionsearch lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch