3ml2 Summary


Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor

The structure was published by Wagner, J., Avvaru, B.S., Robbins, A.H., Scozzafava, A., Supuran, C.T., and McKenna, R., in 2010 in a paper entitled "Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch bicarbonate transportsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch positive regulation of osteoclast differentiationsearch kidney developmentsearch response to pHsearch positive regulation of bone resorptionsearch response to organic substancesearch response to steroid hormonesearch secretionsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch regulation of chloride transportsearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch angiotensin-activated signaling pathwaysearch odontogenesis of dentin-containing toothsearch morphogenesis of an epitheliumsearch response to zinc ionsearch regulation of anion transportsearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch lyase activitysearch plasma membranesearch axonsearch apical part of cellsearch extracellular spacesearch myelin sheathsearch cytosolsearch microvillussearch cytoplasmsearch extracellular vesicular exosomesearch basolateral plasma membranesearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch