3mks Summary

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Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2

The structure was published by Orlicky, S., Tang, X., Neduva, V., et al., Brown, E.D., Sicheri, F., and Tyers, M., in 2010 in a paper entitled "An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Suppressor of kinetochore protein 1 and Cell division control protein 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Suppressor of kinetochore protein 1 P52286 (2-194) (SKP1_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 169 79%
C Suppressor of kinetochore protein 1 P52286 (2-194) (SKP1_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 169 79%
B Cell division control protein 4 P07834 (263-744) (CDC4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 464 95%
D Cell division control protein 4 P07834 (263-744) (CDC4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 464 95%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P52286 (2 - 194) Suppressor of kinetochore protein 1 Saccharomyces cerevisiae
P07834 (263 - 744) Cell division control protein 4 Saccharomyces cerevisiae

Chain Structural classification (CATH) Sequence family (Pfam)
A, C Potassium Channel Kv1.1; Chain Asearch Skp1 family, dimerisation domainsearch, Skp1 family, tetramerisation domainsearch
B, D Monooxygenasesearch, YVTN repeat-like/Quinoprotein amine dehydrogenasesearch WD domain, G-beta repeatsearch, F-box domainsearch

Chain ID Biological process (GO)
A, C (P52286) ubiquitin-dependent protein catabolic processsearch

Chain InterPro annotation
A, C S-phase kinase-associated protein 1-likesearch BTB/POZ foldsearch SKP1 component, dimerisationsearch SKP1 component, POZ domainsearch S-phase kinase-associated protein 1search
B, D WD40 repeatsearch F-box domainsearch WD40/YVTN repeat-like-containing domainsearch WD40-repeat-containing domainsearch WD40 repeat, conserved sitesearch G-protein beta WD-40 repeatsearch