3mk3 Summary

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Crystal structure of Lumazine synthase from Salmonella typhimurium LT2

The structure was published by Kumar, P., Singh, M., and Karthikeyan, S., in 2011 in a paper entitled "Crystal structure analysis of icosahedral lumazine synthase from Salmonella typhimurium, an antibacterial drug target." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.569 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of 6,7-dimethyl-8-ribityllumazine synthase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 60meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
B 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
C 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
D 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
E 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
F 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
G 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
H 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
I 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
J 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
K 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
L 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
M 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
N 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
O 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
P 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
Q 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
R 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
S 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
T 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
U 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
V 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
W 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
X 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
Y 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
Z 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
1 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
2 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
3 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
4 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
5 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
6 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
7 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
8 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
9 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
a 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
b 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
c 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
d 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
e 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
f 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
g 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
h 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
i 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
j 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
k 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
l 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
m 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
n 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
o 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
p 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
q 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
r 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
s 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
t 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
u 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
v 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
w 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
x 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%
y 6,7-dimethyl-8-ribityllumazine synthase P66038 (1-156) (RISB_SALTY)search Salmonella enterica subsp. enterica serovar Typhimurium str. LT2search 100% 156 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P66038 (1 - 156) 6,7-dimethyl-8-ribityllumazine synthase Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2, 3, 4, 5, 6, 7, 8, 9, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y (P66038) Rossmann foldsearch PF00885: 6,7-dimethyl-8-ribityllumazine synthasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2, 3, 4, 5, 6, 7, 8, 9, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y (P66038) riboflavin synthase complexsearch riboflavin biosynthetic processsearch transferase activitysearch 6,7-dimethyl-8-ribityllumazine synthase activitysearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2, 3, 4, 5, 6, 7, 8, 9, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y 6,7-dimethyl-8-ribityllumazine synthasesearch