3mk2 Summary


Placental alkaline phosphatase complexed with Phe

The structure was published by Stec, B., Cheltsov, A., and Millan, J.L., in 2010 in a paper entitled "Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.89 Å and deposited in 2010.

This entry is a re-refinement of an older structure (1zef) using the same experimental data but not carried out by the same authors.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Alkaline phosphatase, placental type. This molecule has the UniProt identifier P05187 (PPB1_HUMAN)search. The sample contained 484 residues which is 94% of the natural sequence. Out of 484 residues 481 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alkaline phosphatase, placental type P05187 (23-503) (PPB1_HUMAN)search Homo sapienssearch 94% 484 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05187 (23 - 503) Alkaline phosphatase, placental type Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P05187) Alkaline Phosphatase, subunit Asearch PF00245: Alkaline phosphatasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P05187) phosphatase activitysearch hydrolase activitysearch metal ion bindingsearch zinc ion bindingsearch catalytic activitysearch alkaline phosphatase activitysearch magnesium ion bindingsearch dephosphorylationsearch metabolic processsearch integral component of membranesearch anchored component of membranesearch cell surfacesearch plasma membranesearch membranesearch

Chain InterPro annotation
A Alkaline phosphatasesearch Alkaline phosphatase-like, alpha/beta/alphasearch Alkaline-phosphatase-like, core domainsearch Alkaline phosphatase, active sitesearch