X-ray crystal structure of ITK complexed with inhibitor RO5191614
The structure was published by Kutach, A.K., Villasenor, A.G., Lam, D., et al., Chu, W., Shaw, D., and Kuglstatter, A., in 2010 in a paper entitled "Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.72 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Tyrosine-protein kinase ITK/TSK. This molecule has the UniProt identifier Q08881 (ITK_HUMAN). The sample contained 266 residues which is < 90% of the natural sequence. Out of 266 residues 228 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: