3miy Summary

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X-ray crystal structure of ITK complexed with sunitinib

The structure was published by Kutach, A.K., Villasenor, A.G., Lam, D., et al., Chu, W., Shaw, D., and Kuglstatter, A., in 2010 in a paper entitled "Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.67 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Tyrosine-protein kinase ITK/TSK.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase ITK/TSK Q08881 (357-620) (ITK_HUMAN)search Homo sapienssearch < 90% 266 90%
B Tyrosine-protein kinase ITK/TSK Q08881 (357-620) (ITK_HUMAN)search Homo sapienssearch < 90% 266 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q08881 (357 - 620) Tyrosine-protein kinase ITK/TSK Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q08881) ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch