3mhm Summary


Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide

The structure was published by Sudzius, J., Baranauskiene, L., Golovenko, D., et al., Grazulis, S., Tumkevicius, S., and Matulis, D., in 2010 in a paper entitled "4-[N-(Substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch protein bindingsearch metal ion bindingsearch one-carbon metabolic processsearch bicarbonate transportsearch morphogenesis of an epitheliumsearch positive regulation of bone resorptionsearch positive regulation of dipeptide transmembrane transportsearch small molecule metabolic processsearch kidney developmentsearch positive regulation of cellular pH reductionsearch regulation of anion transportsearch odontogenesis of dentin-containing toothsearch positive regulation of osteoclast differentiationsearch response to steroid hormonesearch carbon dioxide transportsearch secretionsearch response to zinc ionsearch response to pHsearch regulation of intracellular pHsearch response to organic substancesearch response to estrogensearch angiotensin-activated signaling pathwaysearch extracellular spacesearch membranesearch cytosolsearch microvillussearch cytoplasmsearch plasma membranesearch apical part of cellsearch basolateral plasma membranesearch extracellular vesicular exosomesearch axonsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch