3mhm Summary


Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide

The structure was published by Sudzius, J., Baranauskiene, L., Golovenko, D., et al., Grazulis, S., Tumkevicius, S., and Matulis, D., in 2010 in a paper entitled "4-[N-(Substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch protein bindingsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch positive regulation of osteoclast differentiationsearch positive regulation of cellular pH reductionsearch response to estrogensearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch cellular response to fluid shear stresssearch bicarbonate transportsearch response to organic substancesearch secretionsearch response to steroid hormonesearch small molecule metabolic processsearch regulation of anion transportsearch kidney developmentsearch one-carbon metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of bone resorptionsearch regulation of intracellular pHsearch positive regulation of synaptic transmission, GABAergicsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch response to zinc ionsearch regulation of chloride transportsearch cytosolsearch microvillussearch extracellular spacesearch plasma membranesearch myelin sheathsearch basolateral plasma membranesearch membranesearch axonsearch apical part of cellsearch cytoplasmsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch