3mdz Summary


Crystal Structure of Human Carbonic Anhydrase VII [isoform 1], CA7

The structure was published by Ugochukwu, E., Shafqat, N., Pilka, E., et al., Carpenter, E.P., Yue, W.W., and Oppermann, U., in in a paper entitled "Crystal Structure of Human Carbonic Anhydrase VII [isoform 1], CA7" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.32 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 7. This molecule has the UniProt identifier P43166 (CAH7_HUMAN)search. The sample contained 281 residues which is 98% of the natural sequence. Out of 281 residues 251 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 7 P43166 (5-262) (CAH7_HUMAN)search Homo sapienssearch 98% 281 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P43166 (5 - 262) Carbonic anhydrase 7 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P43166) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P43166) bicarbonate transportsearch one-carbon metabolic processsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch regulation of chloride transportsearch positive regulation of synaptic transmission, GABAergicsearch carbonate dehydratase activitysearch lyase activitysearch zinc ion bindingsearch metal ion bindingsearch cytoplasmsearch cytosolsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase, CA-VIIsearch Carbonic anhydrase, alpha-classsearch