3mdl Summary


X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of cyclooxygenase-2

The structure was published by Vecchio, A.J. and Malkowski, M.G., in 2011 in a paper entitled "The structural basis of endocannabinoid oxygenation by cyclooxygenase-2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (20-599) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B Prostaglandin G/H synthase 2 Q05769 (20-599) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (20 - 599) Prostaglandin G/H synthase 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q05769) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q05769) regulation of blood pressuresearch cellular response to mechanical stimulussearch regulation of cell proliferationsearch response to lithium ionsearch memorysearch cyclooxygenase pathwaysearch response to tumor necrosis factorsearch response to organic substancesearch response to cytokinesearch response to radiationsearch fatty acid metabolic processsearch positive regulation of NF-kappaB import into nucleussearch response to estradiolsearch learningsearch lipid metabolic processsearch embryo implantationsearch positive regulation of brown fat cell differentiationsearch hair cyclesearch oxidation-reduction processsearch prostaglandin biosynthetic processsearch response to oxidative stresssearch response to glucocorticoidsearch cellular response to hypoxiasearch angiogenesissearch positive regulation of vasoconstrictionsearch positive regulation vascular endothelial growth factor productionsearch keratinocyte differentiationsearch inflammatory responsesearch positive regulation of transforming growth factor beta productionsearch response to fatty acidsearch positive regulation of nitric oxide biosynthetic processsearch negative regulation of calcium ion transportsearch ovulationsearch bone mineralizationsearch response to fructosesearch positive regulation of smooth muscle cell proliferationsearch positive regulation of synaptic transmission, glutamatergicsearch response to organonitrogen compoundsearch cellular response to ATPsearch positive regulation of fibroblast growth factor productionsearch negative regulation of synaptic transmission, dopaminergicsearch decidualizationsearch cellular response to UVsearch positive regulation of synaptic plasticitysearch positive regulation of smooth muscle contractionsearch maintenance of blood-brain barriersearch response to manganese ionsearch negative regulation of smooth muscle contractionsearch response to drugsearch positive regulation of platelet-derived growth factor productionsearch negative regulation of cell proliferationsearch response to vitamin Dsearch positive regulation of apoptotic processsearch positive regulation of fever generationsearch negative regulation of cell cyclesearch response to organic cyclic compoundsearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation of cell deathsearch prostaglandin metabolic processsearch fatty acid biosynthetic processsearch response to lipopolysaccharidesearch brown fat cell differentiationsearch sensory perception of painsearch anagensearch lipid bindingsearch oxidoreductase activitysearch heme bindingsearch prostaglandin-endoperoxide synthase activitysearch enzyme bindingsearch peroxidase activitysearch metal ion bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch dioxygenase activitysearch protein homodimerization activitysearch neuron projectionsearch intracellular membrane-bounded organellesearch membranesearch endoplasmic reticulum membranesearch organelle membranesearch protein complexsearch cytoplasmsearch endoplasmic reticulumsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search