3mb6 Summary

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Human CK2 catalytic domain in complex with a difurane derivative inhibitor (CPA)

The structure was published by Lopez-Ramos, M., Prudent, R., Moucadel, V., et al., Knapp, S., Reiser, J.B., and Cochet, C., in 2010 in a paper entitled "New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Casein kinase II subunit alpha. This molecule has the UniProt identifier P68400 (CSK21_HUMAN)search. The sample contained 331 residues which is < 90% of the natural sequence. Out of 331 residues 328 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Casein kinase II subunit alpha P68400 (1-331) (CSK21_HUMAN)search Homo sapienssearch 100% 331 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P68400 (1 - 331) Casein kinase II subunit alpha Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P68400) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P68400) protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch