3m96 Summary


Crystal structure of human carbonic anhydrase isozyme II with 5-{[(5-bromo-1H-benzimidazol-2-yl)sulfanyl]acetyl}-2-chlorobenzenesulfonamide

The structure was published by Baranauskiene, L., Golovenko, D., Manakova, E., Grazulis, S., Tumkevicius, S., and Matulis, D., in 2010 in a paper entitled "Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.4 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch protein bindingsearch metal ion bindingsearch lyase activitysearch zinc ion bindingsearch odontogenesis of dentin-containing toothsearch response to estrogensearch response to zinc ionsearch regulation of anion transportsearch small molecule metabolic processsearch secretionsearch morphogenesis of an epitheliumsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch positive regulation of cellular pH reductionsearch response to pHsearch regulation of intracellular pHsearch response to organic substancesearch bicarbonate transportsearch kidney developmentsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of bone resorptionsearch cellular response to fluid shear stresssearch positive regulation of osteoclast differentiationsearch one-carbon metabolic processsearch cytoplasmsearch cytosolsearch apical part of cellsearch extracellular spacesearch plasma membranesearch extracellular vesicular exosomesearch myelin sheathsearch membranesearch microvillussearch basolateral plasma membranesearch axonsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch