3m67 Summary


Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(6,7-dihydro-1H-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide

The structure was published by Capkauskaite, E., Baranauskiene, L., Golovenko, D., et al., Grazulis, S., Tumkevicius, S., and Matulis, D., in 2010 in a paper entitled "Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) one-carbon metabolic processsearch response to organic substancesearch kidney developmentsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch response to steroid hormonesearch response to pHsearch positive regulation of cellular pH reductionsearch response to estrogensearch secretionsearch positive regulation of osteoclast differentiationsearch regulation of anion transportsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of bone resorptionsearch small molecule metabolic processsearch response to zinc ionsearch odontogenesis of dentin-containing toothsearch axonsearch cytoplasmsearch cytosolsearch apical part of cellsearch membranesearch extracellular vesicular exosomesearch plasma membranesearch microvillussearch extracellular spacesearch myelin sheathsearch basolateral plasma membranesearch protein bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch