3m5t Summary

pdbe.org/3m5t
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Fragment tethered to Carbonic Anhydrase II H64C mutant

A publication describing this structure is not available. The depositing authors are Schulze Wischeler, J.search; Heine, A.search; Klebe, G.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 265 residues which is 100% of the natural sequence. Out of 265 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 265 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) angiotensin-activated signaling pathwaysearch regulation of intracellular pHsearch secretionsearch morphogenesis of an epitheliumsearch positive regulation of osteoclast differentiationsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch regulation of anion transportsearch one-carbon metabolic processsearch response to pHsearch small molecule metabolic processsearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch positive regulation of synaptic transmission, GABAergicsearch kidney developmentsearch regulation of chloride transportsearch response to estrogensearch response to organic substancesearch response to steroid hormonesearch odontogenesis of dentin-containing toothsearch membranesearch basolateral plasma membranesearch cytoplasmsearch apical part of cellsearch cytosolsearch plasma membranesearch extracellular spacesearch myelin sheathsearch extracellular vesicular exosomesearch axonsearch microvillussearch lyase activitysearch zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch