3m5s Summary


Carbonic Anhydrase II mutant H64C in complex with carbonate

The structure was published by Schulze Wischeler, J., Heine, A., and Klebe, G, in in a paper entitled "Mutational study on Carbonic Anhydrase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.4 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 265 residues which is 100% of the natural sequence. Out of 265 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 265 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch lyase activitysearch protein bindingsearch apical part of cellsearch extracellular spacesearch cytoplasmsearch plasma membranesearch cytosolsearch axonsearch extracellular vesicular exosomesearch microvillussearch membranesearch basolateral plasma membranesearch bicarbonate transportsearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch positive regulation of cellular pH reductionsearch response to pHsearch angiotensin-activated signaling pathwaysearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch kidney developmentsearch secretionsearch one-carbon metabolic processsearch response to estrogensearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch morphogenesis of an epitheliumsearch response to organic substancesearch carbon dioxide transportsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch