3m4u Summary

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Crystal Structure of Trypanosoma brucei Protein Tyrosine Phosphatase TbPTP1

The structure was published by Chou, S., Jensen, B.C., Parsons, M., Alber, T., and Grundner, C., in 2010 in a paper entitled "The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein NOPP44/46." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.392 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Tyrosine specific protein phosphatase, putative.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine specific protein phosphatase, putative Q38AT7 (1-306) (Q38AT7_TRYB2)search Trypanosoma brucei brucei strain 927/4 GUTat10.1search 100% 306 93%
B Tyrosine specific protein phosphatase, putative Q38AT7 (1-306) (Q38AT7_TRYB2)search Trypanosoma brucei brucei strain 927/4 GUTat10.1search 100% 306 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q38AT7 (1 - 306) Tyrosine specific protein phosphatase, putative Trypanosoma brucei

Chain Sequence family (Pfam)
A, B (Q38AT7) PF00102: Protein-tyrosine phosphatasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q38AT7) phosphatase activitysearch protein tyrosine phosphatase activitysearch phosphoprotein phosphatase activitysearch hydrolase activitysearch protein dephosphorylationsearch dephosphorylationsearch peptidyl-tyrosine dephosphorylationsearch

Chain InterPro annotation
A, B Protein-tyrosine phosphatase, receptor/non-receptor typesearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch Protein-tyrosine phosphatase-likesearch