3m2z Summary


Fragment tethered to Carbonic Anhydrase II H64C mutant

A publication describing this structure is not available. The depositing authors are Schulze Wischeler, J.search; Heine, A.search; Klebe, G.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 265 residues which is 100% of the natural sequence. Out of 265 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 265 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) apical part of cellsearch cytosolsearch plasma membranesearch axonsearch myelin sheathsearch basolateral plasma membranesearch cytoplasmsearch extracellular spacesearch membranesearch extracellular vesicular exosomesearch microvillussearch odontogenesis of dentin-containing toothsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of osteoclast differentiationsearch bicarbonate transportsearch response to zinc ionsearch response to steroid hormonesearch positive regulation of synaptic transmission, GABAergicsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch response to organic substancesearch one-carbon metabolic processsearch regulation of chloride transportsearch positive regulation of bone resorptionsearch response to estrogensearch cellular response to fluid shear stresssearch small molecule metabolic processsearch morphogenesis of an epitheliumsearch regulation of anion transportsearch secretionsearch response to pHsearch kidney developmentsearch angiotensin-activated signaling pathwaysearch lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch