3m2w Summary


Crystal structure of MAPKAK kinase 2 (MK2) complexed with a spiroazetidine-tetracyclic ATP site inhibitor

The structure was published by Revesz, L., Schlapbach, A., Aichholz, R., et al., Scheufler, C., Velcicky, J., and Huppertz, C., in 2010 in a paper entitled "In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.41 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of MAP kinase-activated protein kinase 2. This molecule has the UniProt identifier P49137 (MAPK2_HUMAN)search. The sample contained 299 residues which is < 90% of the natural sequence. Out of 299 residues 283 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 299 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49137 (47 - 364) MAP kinase-activated protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P49137) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P49137) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch