3m1w Summary


Carbonic Anhyrdase II mutant W5CH64C with closed disulfide bond in complex with sulfate

A publication describing this structure is not available. The depositing authors are Schulze Wischeler, J.search; Heine, A.search; Klebe, G.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.38 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 265 residues which is 100% of the natural sequence. Out of 265 residues 253 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 265 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of osteoclast differentiationsearch regulation of chloride transportsearch response to estrogensearch bicarbonate transportsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch kidney developmentsearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch secretionsearch positive regulation of bone resorptionsearch response to pHsearch small molecule metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of cellular pH reductionsearch response to zinc ionsearch regulation of anion transportsearch angiotensin-activated signaling pathwaysearch response to organic substancesearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch metal ion bindingsearch axonsearch cytosolsearch plasma membranesearch cytoplasmsearch basolateral plasma membranesearch microvillussearch apical part of cellsearch membranesearch extracellular spacesearch extracellular vesicular exosomesearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch