3m1v Summary

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Structural Insight into Methyl-Coenzyme M Reductase Chemistry using Coenzyme B Analogues

The structure was published by Cedervall, P.E., Dey, M., Pearson, A.R., Ragsdale, S.W., and Wilmot, C.M., in 2010 in a paper entitled "Structural insight into methyl-coenzyme m reductase chemistry using coenzyme B analogues ." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.45 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Methyl-coenzyme M reductase I subunit alpha, Methyl-coenzyme M reductase I subunit beta, and Methyl-coenzyme M reductase I subunit gamma.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Methyl-coenzyme M reductase I subunit alpha P11558 (2-550) (MCRA_METTM)search Methanothermobacter marburgensis str. Marburgsearch 100% 549 99%
D Methyl-coenzyme M reductase I subunit alpha P11558 (2-550) (MCRA_METTM)search Methanothermobacter marburgensis str. Marburgsearch 100% 549 99%
B Methyl-coenzyme M reductase I subunit beta P11560 (2-443) (MCRB_METTM)search Methanothermobacter marburgensis str. Marburgsearch 100% 442 100%
E Methyl-coenzyme M reductase I subunit beta P11560 (2-443) (MCRB_METTM)search Methanothermobacter marburgensis str. Marburgsearch 100% 442 100%
C Methyl-coenzyme M reductase I subunit gamma P11562 (2-249) (MCRG_METTM)search Methanothermobacter marburgensis str. Marburgsearch 99% 248 99%
F Methyl-coenzyme M reductase I subunit gamma P11562 (2-249) (MCRG_METTM)search Methanothermobacter marburgensis str. Marburgsearch 99% 248 99%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P11558 (2 - 550) Methyl-coenzyme M reductase I subunit alpha Methanothermobacter marburgensis str. Marburg
P11560 (2 - 443) Methyl-coenzyme M reductase I subunit beta Methanothermobacter marburgensis str. Marburg
P11562 (2 - 249) Methyl-coenzyme M reductase I subunit gamma Methanothermobacter marburgensis str. Marburg

Chain Structural classification (CATH) Sequence family (Pfam)
A, D (P11558) Methyl-coenzyme M Reductase; Chain A, domain 1search, Alpha-Beta Plaitssearch, Methyl-coenzyme M Reductase; Chain B, domain 2search PF02249: Methyl-coenzyme M reductase alpha subunit, C-terminal domainsearch, PF02745: Methyl-coenzyme M reductase alpha subunit, N-terminal domainsearch
B, E (P11560) Methyl-coenzyme M Reductase; Chain B, domain 2search, Alpha-Beta Plaitssearch PF02241: Methyl-coenzyme M reductase beta subunit, C-terminal domainsearch, PF02783: Methyl-coenzyme M reductase beta subunit, N-terminal domainsearch
C, F (P11562) Lambda Exonuclease; Chain Asearch PF02240: Methyl-coenzyme M reductase gamma subunitsearch

Chain ID Molecular function (GO) Biological process (GO)
A, D (P11558) coenzyme-B sulfoethylthiotransferase activitysearch metal ion bindingsearch transferase activitysearch methanogenesissearch
B, E (P11560) coenzyme-B sulfoethylthiotransferase activitysearch transferase activitysearch methanogenesissearch
C, F (P11562) coenzyme-B sulfoethylthiotransferase activitysearch transferase activitysearch methanogenesissearch

Chain InterPro annotation
A, D Methyl-coenzyme M reductase, alpha subunit, N-terminalsearch Methyl-coenzyme M reductase, alpha/beta subunit, C-terminalsearch Methyl-coenzyme M reductase, ferredoxin-like foldsearch Methyl-coenzyme M reductase, alpha subunit, C-terminalsearch Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 1search Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2search Methyl coenzyme M reductase, alpha subunitsearch Methyl-coenzyme M reductase, alpha/beta subunit, domain 2, C-terminalsearch
B, E Methyl-coenzyme M reductase, beta subunitsearch Methyl-coenzyme M reductase, alpha/beta subunit, C-terminalsearch Methyl-coenzyme M reductase, ferredoxin-like foldsearch Methyl-coenzyme M reductase, alpha subunit, N-terminal subdomain 2search Methyl-coenzyme M reductase, beta subunit, C-terminalsearch Methyl-coenzyme M reductase, beta subunit, N-terminalsearch Methyl-coenzyme M reductase, alpha/beta subunit, domain 2, C-terminalsearch
C, F Methyl-coenzyme M reductase, gamma subunitsearch Methyl-coenzyme M reductase, ferredoxin-like foldsearch