3m1s Summary


Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3

The structure was published by Atilla-Gokcumen, G.E., Di Costanzo, L., and Meggers, E., in 2011 in a paper entitled "Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.134 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 83%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 83%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch positive regulation of protein complex assemblysearch cell differentiationsearch positive regulation of protein bindingsearch negative regulation of canonical Wnt signaling pathwaysearch peptidyl-serine phosphorylationsearch ER overload responsesearch intracellular signal transductionsearch negative regulation of protein complex assemblysearch axonogenesissearch nervous system developmentsearch protein export from nucleussearch hypermethylation of CpG islandsearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of cell-matrix adhesionsearch canonical Wnt signaling pathwaysearch superior temporal gyrus developmentsearch circadian rhythmsearch positive regulation of peptidyl-threonine phosphorylationsearch negative regulation of MAP kinase activitysearch Wnt signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch innate immune responsesearch negative regulation of apoptotic processsearch protein localization to microtubulesearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch epithelial to mesenchymal transitionsearch positive regulation of protein catabolic processsearch neurotrophin TRK receptor signaling pathwaysearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of peptidyl-serine phosphorylationsearch regulation of microtubule-based processsearch re-entry into mitotic cell cyclesearch regulation of gene expression by genetic imprintingsearch negative regulation of cardiac muscle hypertrophysearch response to drugsearch negative regulation of dendrite morphogenesissearch negative regulation of glycogen (starch) synthase activitysearch fat cell differentiationsearch negative regulation of glycogen biosynthetic processsearch negative regulation of neuron maturationsearch negative regulation of protein bindingsearch positive regulation of Rac GTPase activitysearch phosphatidylinositol-mediated signalingsearch positive regulation of apoptotic processsearch myotube differentiationsearch multicellular organismal developmentsearch positive regulation of protein export from nucleussearch hippocampus developmentsearch negative regulation of signal transductionsearch cellular response to interleukin-3search negative regulation of NFAT protein import into nucleussearch axon guidancesearch phosphorylationsearch regulation of neuronal synaptic plasticitysearch positive regulation of stem cell differentiationsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch carbohydrate metabolic processsearch myoblast fusionsearch positive regulation of transcription from RNA polymerase II promotersearch rhythmic processsearch glycogen metabolic processsearch cell migrationsearch establishment of cell polaritysearch organ morphogenesissearch negative regulation of neuron projection developmentsearch cellular response to mechanical stimulussearch establishment or maintenance of cell polaritysearch epidermal growth factor receptor signaling pathwaysearch negative regulation of type B pancreatic cell developmentsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch response to lithium ionsearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein kinase A catalytic subunit bindingsearch p53 bindingsearch protein bindingsearch beta-catenin bindingsearch kinase activitysearch tau-protein kinase activitysearch tau protein bindingsearch nucleotide bindingsearch protein kinase bindingsearch ubiquitin protein ligase bindingsearch transferase activitysearch NF-kappaB bindingsearch RNA polymerase II transcription factor bindingsearch integrin bindingsearch ionotropic glutamate receptor bindingsearch perinuclear region of cytoplasmsearch cytosolsearch beta-catenin destruction complexsearch centrosomesearch membranesearch plasma membranesearch cytoplasmsearch dendritic shaftsearch membrane raftsearch membrane-bounded organellesearch nucleussearch dendritic spinesearch neuronal cell bodysearch cell bodysearch growth conesearch protein complexsearch ribonucleoprotein complexsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch