3m1s Summary


Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3

The structure was published by Atilla-Gokcumen, G.E., Di Costanzo, L., and Meggers, E., in 2011 in a paper entitled "Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.134 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 83%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 83%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) Wnt signaling pathwaysearch carbohydrate metabolic processsearch epidermal growth factor receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch establishment or maintenance of cell polaritysearch peptidyl-serine phosphorylationsearch fibroblast growth factor receptor signaling pathwaysearch circadian rhythmsearch positive regulation of stem cell differentiationsearch positive regulation of peptidyl-threonine phosphorylationsearch negative regulation of glycogen (starch) synthase activitysearch negative regulation of MAP kinase activitysearch regulation of gene expression by genetic imprintingsearch negative regulation of signal transductionsearch myoblast fusionsearch negative regulation of apoptotic processsearch positive regulation of protein complex assemblysearch positive regulation of cell-matrix adhesionsearch negative regulation of glycogen biosynthetic processsearch negative regulation of protein bindingsearch positive regulation of Rac GTPase activitysearch negative regulation of cardiac muscle hypertrophysearch positive regulation of apoptotic processsearch canonical Wnt signaling pathwaysearch negative regulation of dendrite morphogenesissearch regulation of microtubule-based processsearch hypermethylation of CpG islandsearch glycogen metabolic processsearch negative regulation of type B pancreatic cell developmentsearch phosphatidylinositol-mediated signalingsearch positive regulation of peptidyl-serine phosphorylationsearch protein phosphorylationsearch regulation of neuronal synaptic plasticitysearch superior temporal gyrus developmentsearch positive regulation of protein export from nucleussearch re-entry into mitotic cell cyclesearch myotube differentiationsearch response to drugsearch extrinsic apoptotic signaling pathway in absence of ligandsearch negative regulation of protein complex assemblysearch ER overload responsesearch cellular response to interleukin-3search hippocampus developmentsearch negative regulation of NFAT protein import into nucleussearch establishment of cell polaritysearch intracellular signal transductionsearch fat cell differentiationsearch phosphorylationsearch positive regulation of protein bindingsearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of protein catabolic processsearch epithelial to mesenchymal transitionsearch Fc-epsilon receptor signaling pathwaysearch innate immune responsesearch rhythmic processsearch neurotrophin TRK receptor signaling pathwaysearch cell migrationsearch nervous system developmentsearch protein localization to microtubulesearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch cellular response to mechanical stimulussearch response to lithium ionsearch protein export from nucleussearch axonogenesissearch axon guidancesearch organ morphogenesissearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch multicellular organismal developmentsearch cell differentiationsearch tau-protein kinase activitysearch protein bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch integrin bindingsearch RNA polymerase II transcription factor bindingsearch beta-catenin bindingsearch protein kinase activitysearch transferase activitysearch protein kinase bindingsearch p53 bindingsearch protein kinase A catalytic subunit bindingsearch ATP bindingsearch ubiquitin protein ligase bindingsearch ionotropic glutamate receptor bindingsearch tau protein bindingsearch NF-kappaB bindingsearch protein complexsearch beta-catenin destruction complexsearch dendritic shaftsearch plasma membranesearch cytoplasmsearch cytosolsearch membranesearch dendritic spinesearch nucleussearch membrane-bounded organellesearch growth conesearch centrosomesearch perinuclear region of cytoplasmsearch ribonucleoprotein complexsearch neuronal cell bodysearch membrane raftsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch