3m1q Summary


Carbonic Anhydrase II mutant W5C-H64C with opened disulfide bond

A publication describing this structure is not available. The depositing authors are Schulze Wischeler, J.search; Heine, A.search; Klebe, G.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.69 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 265 residues which is 100% of the natural sequence. Out of 265 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 265 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) microvillussearch cytoplasmsearch membranesearch cytosolsearch apical part of cellsearch basolateral plasma membranesearch axonsearch extracellular spacesearch plasma membranesearch extracellular vesicular exosomesearch myelin sheathsearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch bicarbonate transportsearch positive regulation of bone resorptionsearch one-carbon metabolic processsearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch response to zinc ionsearch cellular response to fluid shear stresssearch response to estrogensearch regulation of chloride transportsearch regulation of intracellular pHsearch regulation of anion transportsearch positive regulation of synaptic transmission, GABAergicsearch kidney developmentsearch response to pHsearch response to organic substancesearch small molecule metabolic processsearch morphogenesis of an epitheliumsearch secretionsearch odontogenesis of dentin-containing toothsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch