3m1k Summary


Carbonic Anhydrase in complex with fragment

The structure was published by Schulze Wischeler, J., Innocenti, A., Vullo, D., et al., Heine, A., Supuran, C.T., and Klebe, G., in 2010 in a paper entitled "Bidentate Zinc chelators for alpha-carbonic anhydrases that produce a trigonal bipyramidal coordination geometry." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.35 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 265 residues which is 100% of the natural sequence. Out of 265 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 265 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch metal ion bindingsearch lyase activitysearch membranesearch cytoplasmsearch cytosolsearch extracellular vesicular exosomesearch plasma membranesearch axonsearch microvillussearch extracellular spacesearch apical part of cellsearch basolateral plasma membranesearch response to organic substancesearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch positive regulation of dipeptide transmembrane transportsearch secretionsearch regulation of anion transportsearch positive regulation of cellular pH reductionsearch kidney developmentsearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch response to pHsearch regulation of intracellular pHsearch carbon dioxide transportsearch bicarbonate transportsearch response to zinc ionsearch response to estrogensearch positive regulation of bone resorptionsearch angiotensin-activated signaling pathwaysearch response to steroid hormonesearch one-carbon metabolic processsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch