3m14 Summary


Carbonic Anhydrase II in complex with novel sulfonamide inhibitor

A publication describing this structure is not available. The depositing authors are Schulze Wischeler, J.search; Heine, A.search; Klebe, G.search; Sandner, N.U.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.38 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 265 residues which is 100% of the natural sequence. Out of 265 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 265 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) plasma membranesearch cytoplasmsearch basolateral plasma membranesearch cytosolsearch extracellular vesicular exosomesearch axonsearch microvillussearch membranesearch apical part of cellsearch extracellular spacesearch myelin sheathsearch positive regulation of bone resorptionsearch positive regulation of dipeptide transmembrane transportsearch morphogenesis of an epitheliumsearch response to zinc ionsearch bicarbonate transportsearch regulation of intracellular pHsearch small molecule metabolic processsearch response to organic substancesearch angiotensin-activated signaling pathwaysearch one-carbon metabolic processsearch regulation of anion transportsearch positive regulation of cellular pH reductionsearch secretionsearch response to estrogensearch odontogenesis of dentin-containing toothsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch response to pHsearch positive regulation of synaptic transmission, GABAergicsearch cellular response to fluid shear stresssearch kidney developmentsearch regulation of chloride transportsearch carbonate dehydratase activitysearch lyase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch