Crystal Structure of Aurora A Kinase complexed with inhibitor
The structure was published by Coumar, M.S., Chu, C.Y., Lin, C.W., et al., Liao, C.C., Chao, Y.S., and Hsieh, H.P., in 2010 in a paper entitled "Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Serine/threonine-protein kinase 6. This molecule has the UniProt identifier O14965 (AURKA_HUMAN). The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 251 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: