3m11 Summary

pdbe.org/3m11
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Crystal Structure of Aurora A Kinase complexed with inhibitor

The structure was published by Coumar, M.S., Chu, C.Y., Lin, C.W., et al., Liao, C.C., Chao, Y.S., and Hsieh, H.P., in 2010 in a paper entitled "Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.75 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Serine/threonine-protein kinase 6. This molecule has the UniProt identifier O14965 (AURKA_HUMAN)search. The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 251 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase 6 O14965 (123-401) (AURKA_HUMAN)search Homo sapienssearch < 90% 279 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (123 - 401) Serine/threonine-protein kinase 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O14965) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch