3m0w Summary

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Structure of S100A4 with PCP

The structure was published by Ramagopal, U.A., Dulyaninova, N.G., Almo, S.C., and Bresnick, A.R., in in a paper entitled "Structure of S100A4 with PCP" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Protein S100-A4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%
B Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%
C Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%
D Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%
E Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%
F Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%
G Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%
H Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%
I Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%
J Protein S100-A4 P26447 (2-101) (S10A4_HUMAN)search Homo sapienssearch 92% 100 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P26447 (2 - 101) Protein S100-A4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J (P26447) EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D, E, F, G, H, I, J (P26447) protein bindingsearch RAGE receptor bindingsearch calcium-dependent protein bindingsearch calcium ion bindingsearch metal ion bindingsearch identical protein bindingsearch neuron projectionsearch nucleussearch perinuclear region of cytoplasmsearch positive regulation of I-kappaB kinase/NF-kappaB cascadesearch epithelial to mesenchymal transitionsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch