3lxn Summary

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Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

The structure was published by Chrencik, J.E., Patny, A., Leung, I.K., et al., Tenbrink, R.E., Tomasselli, A.G., and Benson, T.E., in 2010 in a paper entitled "Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Non-receptor tyrosine-protein kinase TYK2. This molecule has the UniProt identifier P29597 (TYK2_HUMAN)search. The sample contained 318 residues which is < 90% of the natural sequence. Out of 318 residues 278 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Non-receptor tyrosine-protein kinase TYK2 P29597 (888-1182) (TYK2_HUMAN)search Homo sapienssearch < 90% 318 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29597 (888 - 1182) Non-receptor tyrosine-protein kinase TYK2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P29597) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch