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Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

X-ray diffraction
2Å resolution
PDB entry 3lxk coloured by chain, front view.
PDB entry 3lxk coloured by chain, side view.
PDB entry 3lxk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase JAK3
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Multimeric state: monomeric
Accessible surface area: 13247.23 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156548

Macromolecules

Tyrosine-protein kinase JAK3
Chain: A
Length: 327 amino acids
Theoretical weight: 37.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P52333 (Residues: 806-1124; Coverage: 28%)
Gene name: JAK3
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase JAK3 in PDB entry 3lxk, assembly 1, front view.
Tyrosine-protein kinase JAK3 in PDB entry 3lxk, assembly 1, side view.
Tyrosine-protein kinase JAK3 in PDB entry 3lxk, assembly 1, top view.
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