3lwb Summary

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Crystal Structure of apo D-alanine:D-alanine Ligase (Ddl) from Mycobacterium tuberculosis

The structure was published by Bruning, J.B., Murillo, A.C., Chacon, O., Barletta, R.G., and Sacchettini, J.C., in 2011 in a paper entitled "Structure of the Mycobacterium tuberculosis D-Alanine:D-Alanine Ligase, a Target of the Antituberculosis Drug D-Cycloserine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of D-alanine--D-alanine ligase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A D-alanine--D-alanine ligase P9WP31 (1-373) (DDL_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 373 86%
B D-alanine--D-alanine ligase P9WP31 (1-373) (DDL_MYCTU)search Mycobacterium tuberculosis H37Rvsearch 100% 373 86%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WP31 (1 - 373) D-alanine--D-alanine ligase Mycobacterium tuberculosis

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P9WP31) cytoplasmsearch plasma membranesearch catalytic activitysearch ATP bindingsearch metal ion bindingsearch D-alanine-D-alanine ligase activitysearch nucleotide bindingsearch magnesium ion bindingsearch ligase activitysearch manganese ion bindingsearch protein bindingsearch regulation of cell shapesearch cell wall organizationsearch ATP catabolic processsearch peptidoglycan biosynthetic processsearch growthsearch

Chain InterPro annotation
A, B D-alanine--D-alanine ligase/VANA/B/C, conserved sitesearch D-alanine--D-alanine ligasesearch D-alanine--D-alanine ligase, C-terminalsearch D-alanine--D-alanine ligase, N-terminal domainsearch ATP-grasp foldsearch ATP-grasp fold, subdomain 1search ATP-grasp fold, subdomain 2search Pre-ATP-grasp domainsearch