3lvp Summary

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Crystal structure of bisphosphorylated IGF1-R Kinase domain (2P) in complex with a bis-azaindole inhibitor

The structure was published by Nemecek, C., Metz, W.A., Wentzler, S., et al., Henry, A., Grapinet, S., and Lesuisse, D., in 2010 in a paper entitled "Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Insulin-like growth factor 1 receptor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin-like growth factor 1 receptor P08069 (951-1286) (IGF1R_HUMAN)search Homo sapienssearch < 90% 336 87%
B Insulin-like growth factor 1 receptor P08069 (951-1286) (IGF1R_HUMAN)search Homo sapienssearch < 90% 336 87%
C Insulin-like growth factor 1 receptor P08069 (951-1286) (IGF1R_HUMAN)search Homo sapienssearch < 90% 336 87%
D Insulin-like growth factor 1 receptor P08069 (951-1286) (IGF1R_HUMAN)search Homo sapienssearch < 90% 336 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08069 (951 - 1286) Insulin-like growth factor 1 receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
Chain InterPro annotation
A, B, C, D Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch