3lq3 Summary

pdbe.org/3lq3
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Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

The structure was published by Hong, B.S., Allali-Hassani, A., Tempel, W., et al., Dimov, S., Vedadi, M., and Park, H.W., in 2010 in a paper entitled "Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.42 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Choline/ethanolamine kinase. This molecule has the UniProt identifier Q9Y259 (CHKB_HUMAN)search. The sample contained 401 residues which is 97% of the natural sequence. Out of 401 residues 332 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Choline/ethanolamine kinase Q9Y259 (14-395) (CHKB_HUMAN)search Homo sapienssearch 91% 401 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9Y259 (14 - 395) Choline/ethanolamine kinase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q9Y259) Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2search PF01633: Choline/ethanolamine kinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q9Y259) CDP-choline pathwaysearch phospholipid biosynthetic processsearch phosphorylationsearch lipid metabolic processsearch phosphatidylethanolamine biosynthetic processsearch glycerophospholipid biosynthetic processsearch phosphatidylcholine biosynthetic processsearch muscle organ developmentsearch small molecule metabolic processsearch phospholipid metabolic processsearch ethanolamine kinase activitysearch choline kinase activitysearch kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch ATP bindingsearch nucleotide bindingsearch cytosolsearch

Chain InterPro annotation
A Protein kinase-like domainsearch