3loh Summary

pdbe.org/3loh
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Structure of the insulin receptor ectodomain, including ct peptide

The structure was published by Smith, B.J., Huang, K., Kong, G., et al., Ward, C.W., Weiss, M.A., and Lawrence, M.C., in 2010 in a paper entitled "Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.803 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This entry contains 5 copies of 5 unique biopolymers (complete list).

The molecule most likely forms heterodecamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FAB 83-7 HEAVY CHAIN Not available
Mus musculussearch Not available 220 97%
B FAB 83-7 LIGHT CHAIN Not available
Mus musculussearch Not available 219 100%
C FAB 83-14 HEAVY CHAIN Not available
Mus musculussearch Not available 220 87%
D FAB 83-14 LIGHT CHAIN Not available
Mus musculussearch Not available 214 100%
E Insulin receptor P06213 (28-956) (INSR_HUMAN)search Homo sapienssearch < 90% 917 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06213 (28 - 956) Insulin receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Immunoglobulinssearch
B
C Immunoglobulinssearch
D Immunoglobulinssearch
E Fibronectin type III domainsearch, Furin-like cysteine rich regionsearch, Receptor L domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
E (P06213) transmembrane receptor protein tyrosine kinase signaling pathwaysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch membranesearch

Chain InterPro annotation
A Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
B Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
C Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
D Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin V-set, subgroupsearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
E EGF receptor, L domainsearch Fibronectin type IIIsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch Immunoglobulin-like foldsearch