Structure of celecoxib bound at the COX-2 active site
The structure was published by Wang, J.L., Limburg, D., Graneto, M.J., et al., Talley, J.J., Kiefer, J.R., and Carter, J., in 2010 in a paper entitled "The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: