3lmg Summary

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Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP

The structure was published by Shi, F., Telesco, S.E., Liu, Y., Radhakrishnan, R., and Lemmon, M.A., in 2010 in a paper entitled "ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Receptor tyrosine-protein kinase erbB-3.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Receptor tyrosine-protein kinase erbB-3 P21860 (684-1020) (ERBB3_HUMAN)search Homo sapienssearch < 90% 344 77%
B Receptor tyrosine-protein kinase erbB-3 P21860 (684-1020) (ERBB3_HUMAN)search Homo sapienssearch < 90% 344 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P21860 (684 - 1020) Receptor tyrosine-protein kinase erbB-3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P21860) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Protein kinase-like domainsearch Tyrosine-protein kinase, catalytic domainsearch