3lk0 Summary

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X-ray structure of bovine SC0067,Ca(2+)-S100B

The structure was published by Wilder, P.T., Charpentier, T.H., Liriano, M.A., et al., Toth, E.A., Mackerell, A.D., and Weber, D.J., in 2010 in a paper entitled "In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.04 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Protein S100-B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-B P02638 (1-90) (S100B_BOVIN)search Bos taurussearch 96% 90 100%
B Protein S100-B P02638 (1-90) (S100B_BOVIN)search Bos taurussearch 96% 90 100%
C Protein S100-B P02638 (1-90) (S100B_BOVIN)search Bos taurussearch 96% 90 100%
D Protein S100-B P02638 (1-90) (S100B_BOVIN)search Bos taurussearch 96% 90 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02638 (1 - 90) Protein S100-B Bos taurus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P02638) EF-handsearch PF00036: EF handsearch, PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (P02638) protein bindingsearch protein homodimerization activitysearch RAGE receptor bindingsearch S100 protein bindingsearch metal ion bindingsearch calcium-dependent protein bindingsearch calcium ion bindingsearch zinc ion bindingsearch identical protein bindingsearch kinase inhibitor activitysearch tau protein bindingsearch cytoplasmsearch nucleussearch rufflesearch perinuclear region of cytoplasmsearch intracellular membrane-bounded organellesearch neuronal cell bodysearch learning or memorysearch positive regulation of complement activationsearch astrocyte activationsearch regulation of translationsearch regulation of neuronal synaptic plasticitysearch phosphorylationsearch axonogenesissearch memorysearch negative regulation of phosphorylationsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch

Chain InterPro annotation
A, B, C, D S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch