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Recombinant human acetylcholinesterase

X-ray diffraction
3.2Å resolution
PDB entry 3lii coloured by chain, front view.
PDB entry 3lii coloured by chain, side view.
PDB entry 3lii coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Acetylcholinesterase
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Multimeric state: homo dimer
Accessible surface area: 38407.95 Å2
Buried surface area: 4709.31 Å2
Dissociation area: 1,099.19 Å2
Dissociation energy (ΔGdiss): 8.06 kcal/mol
Dissociation entropy (TΔSdiss): 14.54 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-149584

Macromolecules

Acetylcholinesterase
Chains: A, B
Length: 540 amino acids
Theoretical weight: 59.23 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: P22303 (Residues: 35-574; Coverage: 93%)
Gene name: ACHE
Pfam: Carboxylesterase family
InterPro:
CATH: alpha/beta hydrolase
Acetylcholinesterase in PDB entry 3lii, assembly 1, front view.
Acetylcholinesterase in PDB entry 3lii, assembly 1, side view.
Acetylcholinesterase in PDB entry 3lii, assembly 1, top view.
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