3lfq Summary


Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor

The structure was published by Lesuisse, D., Dutruc-Rosset, G., Tiraboschi, G., et al., Burgevin, M.C., Quarteronet, D., and Rooney, T., in 2010 in a paper entitled "Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.03 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 289 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P24941) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch cyclin bindingsearch kinase activitysearch nucleotide bindingsearch transferase activitysearch protein serine/threonine kinase activitysearch metal ion bindingsearch histone kinase activitysearch nucleussearch cytosolsearch nucleoplasmsearch cytoskeletonsearch endosomesearch cytoplasmsearch centrosomesearch chromosome, telomeric regionsearch X chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch transcription factor complexsearch Cajal bodysearch microtubule organizing centersearch Y chromosomesearch condensed chromosomesearch centrosome duplicationsearch mitotic G1 DNA damage checkpointsearch DNA repairsearch meiotic nuclear divisionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch phosphorylationsearch cellular response to nitric oxidesearch protein phosphorylationsearch G2/M transition of mitotic cell cyclesearch DNA replicationsearch histone phosphorylationsearch cellular response to DNA damage stimulussearch G1/S transition of mitotic cell cyclesearch mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch Ras protein signal transductionsearch positive regulation of cell proliferationsearch regulation of gene silencingsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch positive regulation of DNA-dependent DNA replication initiationsearch cell divisionsearch mitotic nuclear divisionsearch cell cyclesearch blood coagulationsearch positive regulation of transcription, DNA-templatedsearch potassium ion transportsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch