3lfn Summary


Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor

The structure was published by Lesuisse, D., Dutruc-Rosset, G., Tiraboschi, G., et al., Burgevin, M.C., Quarteronet, D., and Rooney, T., in 2010 in a paper entitled "Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.28 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 285 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch transferase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch protein serine/threonine kinase activitysearch histone kinase activitysearch cyclin bindingsearch kinase activitysearch metal ion bindingsearch nucleotide bindingsearch protein phosphorylationsearch cell cyclesearch meiotic nuclear divisionsearch regulation of gene silencingsearch Ras protein signal transductionsearch mitotic G1 DNA damage checkpointsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch histone phosphorylationsearch positive regulation of cell proliferationsearch positive regulation of transcription, DNA-templatedsearch DNA replicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to DNA damage stimulussearch cell divisionsearch blood coagulationsearch DNA repairsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic cell cyclesearch G1/S transition of mitotic cell cyclesearch cellular response to nitric oxidesearch mitotic nuclear divisionsearch centrosome duplicationsearch phosphorylationsearch potassium ion transportsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch nucleoplasmsearch cytosolsearch endosomesearch nucleussearch microtubule organizing centersearch cyclin-dependent protein kinase holoenzyme complexsearch cytoskeletonsearch Cajal bodysearch chromosome, telomeric regionsearch cytoplasmsearch condensed chromosomesearch centrosomesearch X chromosomesearch transcription factor complexsearch Y chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch