3lfn Summary


Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor

The structure was published by Lesuisse, D., Dutruc-Rosset, G., Tiraboschi, G., et al., Burgevin, M.C., Quarteronet, D., and Rooney, T., in 2010 in a paper entitled "Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.28 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 285 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch histone kinase activitysearch kinase activitysearch cyclin bindingsearch nucleotide bindingsearch transferase activitysearch metal ion bindingsearch protein phosphorylationsearch mitotic G2 phasesearch positive regulation of cell proliferationsearch G2/M transition of mitotic cell cyclesearch cellular response to DNA damage stimulussearch mitotic cell cyclesearch blood coagulationsearch potassium ion transportsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch DNA replicationsearch centrosome duplicationsearch histone phosphorylationsearch G1/S transition of mitotic cell cyclesearch cell cyclesearch cellular response to nitric oxidesearch cell divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch DNA repairsearch mitotic nuclear divisionsearch meiotic nuclear divisionsearch regulation of gene silencingsearch Ras protein signal transductionsearch mitotic G1 DNA damage checkpointsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch nucleoplasmsearch nucleussearch chromosome, telomeric regionsearch cytoplasmsearch endosomesearch centrosomesearch Y chromosomesearch cytosolsearch condensed chromosomesearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch transcription factor complexsearch cytoskeletonsearch microtubule organizing centersearch X chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch