3lfd Summary


Human p38 MAP Kinase in Complex with RL113

A publication describing this structure is not available. The depositing authors are Gruetter, C.search; Simard, J.R.search; Getlik, M.search; Rauh, D.search

This crystal structure was determined using X-ray diffraction at a resolution of 3.4 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 328 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein bindingsearch transferase activitysearch MAP kinase kinase activitysearch nucleotide bindingsearch MAP kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch regulation of sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch peptidyl-serine phosphorylationsearch toll-like receptor 10 signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch fatty acid oxidationsearch chemotaxissearch neurotrophin TRK receptor signaling pathwaysearch activation of MAPK activitysearch platelet activationsearch toll-like receptor 4 signaling pathwaysearch osteoclast differentiationsearch signal transduction in response to DNA damagesearch regulation of transcription from RNA polymerase II promotersearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch protein phosphorylationsearch positive regulation of myoblast differentiationsearch toll-like receptor signaling pathwaysearch transcription, DNA-templatedsearch lipopolysaccharide-mediated signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of myotube differentiationsearch cartilage condensationsearch positive regulation of blood vessel endothelial cell migrationsearch vascular endothelial growth factor receptor signaling pathwaysearch mRNA metabolic processsearch glucose metabolic processsearch toll-like receptor 5 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch phosphorylationsearch Ras protein signal transductionsearch cellular component movementsearch chondrocyte differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch DNA damage checkpointsearch positive regulation of myoblast fusionsearch cell morphogenesissearch angiogenesissearch positive regulation of erythrocyte differentiationsearch 3'-UTR-mediated mRNA stabilizationsearch striated muscle cell differentiationsearch cellular response to ionizing radiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch toll-like receptor 9 signaling pathwaysearch innate immune responsesearch positive regulation of muscle cell differentiationsearch stress-induced premature senescencesearch p38MAPK cascadesearch toll-like receptor 3 signaling pathwaysearch cellular response to DNA damage stimulussearch gene expressionsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch intracellular signal transductionsearch muscle cell differentiationsearch TRIF-dependent toll-like receptor signaling pathwaysearch stress-activated MAPK cascadesearch response to muramyl dipeptidesearch positive regulation of protein import into nucleussearch skeletal muscle tissue developmentsearch cell surface receptor signaling pathwaysearch blood coagulationsearch response to stresssearch apoptotic processsearch positive regulation of reactive oxygen species metabolic processsearch cellular response to vascular endothelial growth factor stimulussearch response to lipopolysaccharidesearch RNA metabolic processsearch signal transductionsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to lipopolysaccharidesearch nucleoplasmsearch extracellular vesicular exosomesearch cytosolsearch nucleussearch cytoplasmsearch mitochondrionsearch cellsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch