3lfb Summary


Human p38 MAP Kinase in Complex with RL98

A publication describing this structure is not available. The depositing authors are Gruetter, C.search; Simard, J.R.search; Getlik, M.search; Rauh, D.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 331 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch protein bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch MAP kinase kinase activitysearch kinase activitysearch transferase activitysearch nucleotide bindingsearch protein phosphorylationsearch toll-like receptor 4 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch activation of MAPK activitysearch blood coagulationsearch lipopolysaccharide-mediated signaling pathwaysearch MAPK cascadesearch phosphorylationsearch platelet activationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch regulation of transcription, DNA-templatedsearch peptidyl-serine phosphorylationsearch glucose metabolic processsearch response to muramyl dipeptidesearch gene expressionsearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch cellular response to DNA damage stimulussearch MyD88-dependent toll-like receptor signaling pathwaysearch osteoclast differentiationsearch cellular component movementsearch signal transductionsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch toll-like receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch cell morphogenesissearch angiogenesissearch cartilage condensationsearch positive regulation of muscle cell differentiationsearch RNA metabolic processsearch chemotaxissearch cellular response to lipopolysaccharidesearch positive regulation of myotube differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch innate immune responsesearch striated muscle cell differentiationsearch cell surface receptor signaling pathwaysearch transcription, DNA-templatedsearch toll-like receptor 2 signaling pathwaysearch mRNA metabolic processsearch positive regulation of myoblast differentiationsearch cellular response to ionizing radiationsearch positive regulation of transcription from RNA polymerase II promotersearch intracellular signal transductionsearch p38MAPK cascadesearch skeletal muscle tissue developmentsearch toll-like receptor 3 signaling pathwaysearch stress-activated MAPK cascadesearch signal transduction in response to DNA damagesearch positive regulation of reactive oxygen species metabolic processsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of protein import into nucleussearch response to stresssearch regulation of transcription from RNA polymerase II promotersearch positive regulation of myoblast fusionsearch apoptotic processsearch toll-like receptor 5 signaling pathwaysearch response to lipopolysaccharidesearch chondrocyte differentiationsearch fatty acid oxidationsearch TRIF-dependent toll-like receptor signaling pathwaysearch stress-induced premature senescencesearch Ras protein signal transductionsearch DNA damage checkpointsearch 3'-UTR-mediated mRNA stabilizationsearch muscle cell differentiationsearch nucleoplasmsearch cytoplasmsearch cytosolsearch nucleussearch cellsearch extracellular vesicular exosomesearch spindle polesearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch