› 3lfb

X-ray diffraction
2.6Å resolution

Human p38 MAP Kinase in Complex with RL98

Released:
DOI: 10.2210/pdb3lfb/pdb
PDB entry 3lfb coloured by chain, front view.
PDB entry 3lfb coloured by chain, side view.
PDB entry 3lfb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gruetter C, Simard JR, Getlik M, Rauh D

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 41.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand Z87 1 x Z87
Ligand BOG 1 x BOG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P212121
Unit cell:
a: 67.12Å b: 69.89Å c: 74.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.23 0.32
Expression system: Escherichia coli

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