3lfa Summary


Human p38 MAP Kinase in Complex with Dasatinib

A publication describing this structure is not available. The depositing authors are Gruetter, C.search; Simard, J.R.search; Getlik, M.search; Rauh, D.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 330 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch protein bindingsearch protein serine/threonine kinase activitysearch MAP kinase activitysearch NFAT protein bindingsearch protein kinase activitysearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch kinase activitysearch MAP kinase kinase activitysearch Ras protein signal transductionsearch RNA metabolic processsearch cellular response to DNA damage stimulussearch gene expressionsearch innate immune responsesearch positive regulation of myotube differentiationsearch striated muscle cell differentiationsearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor 2 signaling pathwaysearch p38MAPK cascadesearch myoblast differentiation involved in skeletal muscle regenerationsearch cellular component movementsearch toll-like receptor 9 signaling pathwaysearch positive regulation of protein import into nucleussearch MyD88-independent toll-like receptor signaling pathwaysearch blood coagulationsearch signal transduction in response to DNA damagesearch negative regulation of canonical Wnt signaling pathwaysearch protein phosphorylationsearch platelet activationsearch MyD88-dependent toll-like receptor signaling pathwaysearch fatty acid oxidationsearch cartilage condensationsearch chondrocyte differentiationsearch positive regulation of myoblast fusionsearch positive regulation of erythrocyte differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor 4 signaling pathwaysearch response to lipopolysaccharidesearch transcription, DNA-templatedsearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of myoblast differentiationsearch muscle cell differentiationsearch TRIF-dependent toll-like receptor signaling pathwaysearch response to stresssearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch intracellular signal transductionsearch toll-like receptor 5 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch chemotaxissearch peptidyl-serine phosphorylationsearch mRNA metabolic processsearch toll-like receptor 3 signaling pathwaysearch cellular response to lipopolysaccharidesearch cell morphogenesissearch positive regulation of reactive oxygen species metabolic processsearch regulation of transcription, DNA-templatedsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch stress-activated MAPK cascadesearch angiogenesissearch phosphorylationsearch 3'-UTR-mediated mRNA stabilizationsearch DNA damage checkpointsearch glucose metabolic processsearch toll-like receptor 10 signaling pathwaysearch positive regulation of muscle cell differentiationsearch osteoclast differentiationsearch cellular response to vascular endothelial growth factor stimulussearch activation of MAPK activitysearch vascular endothelial growth factor receptor signaling pathwaysearch signal transductionsearch toll-like receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch response to muramyl dipeptidesearch skeletal muscle tissue developmentsearch apoptotic processsearch cellular response to ionizing radiationsearch stress-induced premature senescencesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cell surface receptor signaling pathwaysearch nucleoplasmsearch cytoplasmsearch cytosolsearch nucleussearch cellsearch mitochondrionsearch spindle polesearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch